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Rev. Pearl was born in and lived much of her young life in Gaines, Orleans County. She studied for Spiritualist Ministry New York City under the General Assembly of Spiritualist Churches, and eventually moved to Rochester after she married Carl S. Tygart, who worked for the New York State Rail Road.
On March 12 1944 Rev. Pearl stepped down from her position as Pastor of True Brotherhood to devote her time to charity and missionary work. In a farewell ceremony she installed Rev. Rosalind Glasser as Pastor, formerly of Golden Rod Spiritualist Church in Buffalo, NY, as the Pastor of the Church of True Brotherhood.
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Rev. Pearl was known for her acts of kindness and devotion to the people of Rochester. Under her leadership at the Mission she collected clothes, food, and money for families in the area.
She volunteered several weekends to taking orphans at Hillside Children's Center on picnics, and was a frequent visitor to patients in the Veterans Hospital in Batavia, who she took fruit, candy, tobacco, and other gifts.Rev. Pearl was also a member of the Rebekahs, and the Lily Dale Spiritualist Assembly.
In 1963 Rev. Pearl Tygart passed away due to injuries from a car accident. After her passing Anderson Park Spiritualist Mission and Church closed after some 30 years of serving the people of Rochester.